Multiple Choice Questions (MCQs)
Mfold gives out (output) several structures along with their ________.
The greater the number of bonds between the amino acids, the ________ stable a protein becomes.
The major element of secondary structure in myoglobin and hemoglobin is:
An alpha helix is formed by hydrogen bonding between the hydrogen of an amine group and the backbone carbonyl group how many amino acids upstream of it?
DNA makes RNA and RNA makes protein, this process is termed as
What are 2 things required in order to successfully use the dynamic programming technique?
In the alpha helix the hydrogen bond:
Which one of the following methods can be used for statistical evaluation of data?
Which of the following is not a benefit or a factual of FASTA over BLAST?
The Alignment method suitable for finding out conserved patterns in DNA or Protein sequences is
Choose the incorrect statement out of the following?
Beeta-pleated sheets are the examples of ________.
Alpha helices and beta sheets are formed because of ________.
Which of the following methods are broad class of computational algorithms that rely on repeated random sampling to obtain numerical results.
Nussinov-Jacobson (NJ) Algorithm is a dynamic Programming (DP) strategy to predict ________.
Which of the following is the smallest of the RNAs?
Ribbon diagram use cylinders or spiral ribbons to represent alpha-helices and broad, flat arrows to represent beeta-strands.
Analyzing or comparing entire genome of species known as,
74- Scoring Matrices contains,
Which one of the following are Archaea?
Beta Sheets are secondary structure that can be formed as a result of ________.
If two atoms are participating in a covalent bond, their distance will be equal to?
Zuker's Algorithm involves energy ________.
Bioinformatics is the interdisciplinary relative new development of ________.
Messenger RNA is only ________ of RNA content in the cell.
rRNA is synthesized by:
Which one of the following is not a tool for protein visualization?
The procedure of aligning two sequences by searching of patterns that is in the same order in the sequences?
The correct order of progressive alignment steps for multiple sequence alignment is ________ .
The putative ORF can be translated into a protein sequence, which is then used to search against a protein database.
Which one of the following is not a "Sequence Alignment Tool"?
RNA is found in the nucleolus of the cell and DNA is found in
Which of the following is untrue about the Unweighted Pair Group Method Using Arithmetic Average?
For which one of the following activities, bioinformatics is used in modern biological sciences?
In a similar way to structure prediction methods can be evaluated using RMSD to measure the similarity between two molecular complexes.
The basic idea of thermodynamic stability is to maximize bonding in order to minimize the free energy.
Black analysis methods use substitution matrices such as the PAM and BLOSUM matrices to score matches.
Which of the following is the correct order of organization of genetic material from largest to smallest?
FASTA format start with ________ symbol.
Translation is the process in which
Which algorithm is used by global alignment?
There are 64 codons in the genetic dictionary as:
Block analysis methods use substitution matrices such as the PAM and BLOSUM matrices to score matches.
In Corey-Paulin-Koltun Diagram, each atom is represented by ________.
mRNA directs the building of proteins through a sequence of
In Bottom up proteomics, Enzyme ________ is used to cleave the proteins.
To determine the number of each type of interaction within a protein, we need to find its inter atomic distances.
Which of the following is untrue anout the modification of PAM matrices?
What is the source of protein structures in SCOP and CATH?
Progressive alignment methods use the dynamic programming method to build a MSA starting with the most related sequences and then progressively adding less related sequences or groups of sequences to the initial alignment?
Alpha Helices are formed by hydrogen bonding between ________ and ________ atoms in the protein backbone?
Your lab partner is using BLAST, and his best E-value is 3. This means that
Addition or removal of amino acids from protein sequences or nucleotides from DNA or RNA sequences is known as?
Amino acids are mostly synthesized from
________ compares protein sequence against protein databases.
CLUSTALW is a more recent version of CLUSTAL with the W standing for ________.
In dynamic programming we can do multiple sequence alignment upto ________
Bioinformatics can deliver:
Sum of stabilizing and destabilizing energies can help determine the ________.
Who discovered diffraction pattern for DNA?
Which of the following doesn't describe local alignment?
GeneBank and UniPort have
Amino acids are joined together to form polypeptides. Each amino acid is attached to another by a peptide bond. What functional group is created when amino acids are joined together?
All are nucleotide sequence database, except
Which is the default scoring matrix used in BLAST?
Which one of the following types of bond is principally responsible for holding the α-helix shape of a protein secondary structure?
A Protein Data Bank (PDB) data file for a protein structure contains only x and y coordinates of atoms.
Elongation of transcription and RNA processing are all interconnected?
In GenBank, specific gene can be searched by using?
X-Ray data need a minimum of ________ resolution.
Name any two frequently used scoring matrices
Which of the following is not a variant of BLAST?
Which of the following doesn't describe PAM matrices?
Which of the following is the character based phylogenetic tree construction methods?
The BLAST program was developed in ________ .
X-ray diffraction data helps measure ________.
The ________ tool compares nucleotide sequence against DNA database.
GenBank and SWISSPORT are example of
The identification of drugs through genomic study is known as
Messenger RNA is
BLASTX uses protein sequences as queries to search against a protein sequence database.
Which of the following statements about amino acids is correct?
All of the following are protein sequence databases except ________.
In multiple sequence alignment ________ .
Dynamic Programming uses a "________" to deal with matches, mismatches and gaps.
C-Alpha atoms are traced to recreate the ________ protein structure.
RNA is the genetic material in
Which of the following is not protein fragmentation technique.
The interactions which holds and stabilizes the sub-units in 4' structure of proteins are:
Which of these bonds is not involved in forming the secondary structure of a protein?
In multiple sequence alignment (MSA), we have ________ .
Dot plot of repeating elements would be small crosses on plot.
The Phi and Psi values of a Beta-strand composed of all D-amino acids will mainly occupy which quadrant in the Ramachandran plot?
Unfolding of a protein can be termed as ________.
All of the following are protein sequence database, except ________.
The study of full complement of proteins expressed by a genome is called
Which of the following is not an ionization techniques in proteins?
Which of the following is not a benefit of BLAST?
The ________ E-Value, the more significant the hit.
Which one of the following issues are addressed by using computational methods, data processing techniques and algorithms?
Balls and sticks are solid spheres and rods, representing atoms and bond, respectively.
How many proteins does the human body produce?
Laboratory work using computers and computer-generated models generally offline is referred as:
The secondary structure of a protein consists of all but one of the following, which is odd one out?
________ are the units of proteins.
The first RNA processing event is
Single letter code of Tyrosine is ________.
How many types of secondary structures can be formed possibly by folding of RNA?
The peptide bond in protein is:
The scoring of gaps in a MSA (Multiple Sequence Alignment) has to be performed in a different manner from scoring gaps in a pair-wise alignment?
GenBank database is maintained by ________.
X-Ray Crystallography data shows that hydrogen atoms of N-Term may come together with Oxygen atoms of C-term amino acid at ________ position.
Amino acids are chained together by ________.
Visualization methods are very important in viewing molecular properties on molecules. Of particular note is the rendering of molecular surfaces according to their various properties (that can be expressed numerically).
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