Multiple Choice Questions (MCQs)
74- Scoring Matrices contains,
Which of the following is not an ionization techniques in proteins?
In the alpha helix the hydrogen bond:
Which of the following is the character based phylogenetic tree construction methods?
CLUSTALW is a more recent version of CLUSTAL with the W standing for ________.
A Protein Data Bank (PDB) data file for a protein structure contains only x and y coordinates of atoms.
In GenBank, specific gene can be searched by using?
Choose the incorrect statement out of the following?
If two atoms are participating in a covalent bond, their distance will be equal to?
Alpha Helices are formed by hydrogen bonding between ________ and ________ atoms in the protein backbone?
Mfold gives out (output) several structures along with their ________.
What are 2 things required in order to successfully use the dynamic programming technique?
The correct order of progressive alignment steps for multiple sequence alignment is ________ .
The ________ E-Value, the more significant the hit.
The identification of drugs through genomic study is known as
Which of the following is untrue anout the modification of PAM matrices?
Which of the following is not a benefit of BLAST?
Which of these bonds is not involved in forming the secondary structure of a protein?
An alpha helix is formed by hydrogen bonding between the hydrogen of an amine group and the backbone carbonyl group how many amino acids upstream of it?
In a similar way to structure prediction methods can be evaluated using RMSD to measure the similarity between two molecular complexes.
Who discovered diffraction pattern for DNA?
Which of the following is not protein fragmentation technique.
Bioinformatics is the interdisciplinary relative new development of ________.
Which algorithm is used by global alignment?
Visualization methods are very important in viewing molecular properties on molecules. Of particular note is the rendering of molecular surfaces according to their various properties (that can be expressed numerically).
Which one of the following is not a "Sequence Alignment Tool"?
What is the source of protein structures in SCOP and CATH?
Your lab partner is using BLAST, and his best E-value is 3. This means that
Which of the following statements about amino acids is correct?
Which of the following is not a variant of BLAST?
Messenger RNA is only ________ of RNA content in the cell.
The procedure of aligning two sequences by searching of patterns that is in the same order in the sequences?
There are 64 codons in the genetic dictionary as:
The BLAST program was developed in ________ .
Block analysis methods use substitution matrices such as the PAM and BLOSUM matrices to score matches.
Which of the following is the smallest of the RNAs?
Nussinov-Jacobson (NJ) Algorithm is a dynamic Programming (DP) strategy to predict ________.
Zuker's Algorithm involves energy ________.
The putative ORF can be translated into a protein sequence, which is then used to search against a protein database.
Ribbon diagram use cylinders or spiral ribbons to represent alpha-helices and broad, flat arrows to represent beeta-strands.
X-Ray data need a minimum of ________ resolution.
Translation is the process in which
In Bottom up proteomics, Enzyme ________ is used to cleave the proteins.
Beta Sheets are secondary structure that can be formed as a result of ________.
Analyzing or comparing entire genome of species known as,
All of the following are protein sequence database, except ________.
The study of full complement of proteins expressed by a genome is called
Alpha helices and beta sheets are formed because of ________.
Which of the following is untrue about the Unweighted Pair Group Method Using Arithmetic Average?
GenBank and SWISSPORT are example of
Which one of the following issues are addressed by using computational methods, data processing techniques and algorithms?
Which one of the following are Archaea?
Single letter code of Tyrosine is ________.
Which is the default scoring matrix used in BLAST?
Which of the following methods are broad class of computational algorithms that rely on repeated random sampling to obtain numerical results.
Which one of the following methods can be used for statistical evaluation of data?
The greater the number of bonds between the amino acids, the ________ stable a protein becomes.
The major element of secondary structure in myoglobin and hemoglobin is:
In dynamic programming we can do multiple sequence alignment upto ________
Name any two frequently used scoring matrices
X-Ray Crystallography data shows that hydrogen atoms of N-Term may come together with Oxygen atoms of C-term amino acid at ________ position.
The Alignment method suitable for finding out conserved patterns in DNA or Protein sequences is
In Corey-Paulin-Koltun Diagram, each atom is represented by ________.
Which of the following is the correct order of organization of genetic material from largest to smallest?
RNA is found in the nucleolus of the cell and DNA is found in
mRNA directs the building of proteins through a sequence of
For which one of the following activities, bioinformatics is used in modern biological sciences?
Bioinformatics can deliver:
FASTA format start with ________ symbol.
Black analysis methods use substitution matrices such as the PAM and BLOSUM matrices to score matches.
Messenger RNA is
The peptide bond in protein is:
The basic idea of thermodynamic stability is to maximize bonding in order to minimize the free energy.
X-ray diffraction data helps measure ________.
The scoring of gaps in a MSA (Multiple Sequence Alignment) has to be performed in a different manner from scoring gaps in a pair-wise alignment?
Sum of stabilizing and destabilizing energies can help determine the ________.
Laboratory work using computers and computer-generated models generally offline is referred as:
Amino acids are joined together to form polypeptides. Each amino acid is attached to another by a peptide bond. What functional group is created when amino acids are joined together?
DNA makes RNA and RNA makes protein, this process is termed as
Elongation of transcription and RNA processing are all interconnected?
All of the following are protein sequence databases except ________.
Which one of the following types of bond is principally responsible for holding the α-helix shape of a protein secondary structure?
All are nucleotide sequence database, except
Balls and sticks are solid spheres and rods, representing atoms and bond, respectively.
rRNA is synthesized by:
To determine the number of each type of interaction within a protein, we need to find its inter atomic distances.
GenBank database is maintained by ________.
BLASTX uses protein sequences as queries to search against a protein sequence database.
C-Alpha atoms are traced to recreate the ________ protein structure.
Dot plot of repeating elements would be small crosses on plot.
Addition or removal of amino acids from protein sequences or nucleotides from DNA or RNA sequences is known as?
In multiple sequence alignment (MSA), we have ________ .
RNA is the genetic material in
Which of the following doesn't describe PAM matrices?
Which of the following is not a benefit or a factual of FASTA over BLAST?
The ________ tool compares nucleotide sequence against DNA database.
The first RNA processing event is
Which of the following doesn't describe local alignment?
The Phi and Psi values of a Beta-strand composed of all D-amino acids will mainly occupy which quadrant in the Ramachandran plot?
Amino acids are mostly synthesized from
GeneBank and UniPort have
________ are the units of proteins.
Which one of the following is not a tool for protein visualization?
Amino acids are chained together by ________.
Dynamic Programming uses a "________" to deal with matches, mismatches and gaps.
In multiple sequence alignment ________ .
Progressive alignment methods use the dynamic programming method to build a MSA starting with the most related sequences and then progressively adding less related sequences or groups of sequences to the initial alignment?
How many proteins does the human body produce?
How many types of secondary structures can be formed possibly by folding of RNA?
________ compares protein sequence against protein databases.
The interactions which holds and stabilizes the sub-units in 4' structure of proteins are:
Beeta-pleated sheets are the examples of ________.
The secondary structure of a protein consists of all but one of the following, which is odd one out?
Unfolding of a protein can be termed as ________.
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